Hydrocephalus Clinic

Basic Science Research in  Hydrocephalus- the Future of Treatment

Dr. Timothy W. Vogel, M.D. has extensive experience as a developmental neuroscientist with the Vogel Lab that focuses on on cilia signaling in neural progenitor cells in murine models of hydrocephalus. He has led a lab of 13 scientists and trainees who look at hydrocephalus using biochemical, cellular, neuroscience, genetic, and developmental biology methods.

 

The major goals of Dr. Vogel's research is to understand the neural stem cell differentiation and ciliary signaling mechanisms that lead to hydrocephalus, a common neural developmental condition seen in humans (For details see Nature Medicine 18,1797–1804 (2012)).

 

Our lab employs a number of ciliopathy mouse genetic models with in vivo and in vitro systems to study the genesis of hydrocephalus. These include novel in vivo cilia subcellular imaging techniques, molecular/cellular neurobiology, protein biochemistry, genetic, and pharmacological methods.

 

We have ongoing collaborations with Massachusetts General Hospital at Harvard Medical School and Howard Hughes Medical Institute (HHMI) labs. Our lab has a strong interest in translational neuroscience research and is focused on developing novel medical therapies for hydrocephalus.  
 

 

Genetics studies in hydrocephalus

 

Our lab initiated the first multi-institutional study on the genetics of hydrocephalus with the HUGS study. With help from the Hydrocephalus Association, Dr. Vogel and his collaborators have identified novel genetic mutations possibly responsible for genes in families with hydrocephalus.

 

Imaging studies in hydrocephalus

 

The Vogel Lab is actively pursuing their long-standing research collaboration with Massachusetts General Hospital at Harvard Medical School. The ongoing projects relate to novel imaging methods in hydrocephalus and have produced promising results and innovations into this disease. Contact Dr. Vogel to learn more.

 

Contact the Vogel lab
 

We have an established record of training highly qualified postdoctoral fellows, residents, medical students, medical fellows, neurologists, undergraduates and interested parties whohave experience in research. If you are interested in a position please contact us.