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Pediatric Brain Tumor Program

Pediatric Brain Tumor Research at Hackensack University Medical Center and the Joseph M. Sanzari Children's Hospital



Clinical Trials

The Pediatric Neuro-oncology Program at the Joseph M. Sanzari Children’s Hospital is dedicated to meeting the clinical and research needs of children with brain and spinal cord tumors.  Our program aims to provide patients with access to early-stage trials of the newest and most-innovative brain tumor therapies. We deliver multidisciplinary care involving a team of pediatric neuro-oncologists, neurosurgeons, neurologists, radiation oncologists, radiologists, pathologists, and neuropsychologists. Our focus is to provide exceptional care with the goal of not only on treating the patient’s tumor, but ensuring good long-term outcomes that maximize the function and quality of life of the children we treat.


Our program is dedicated to finding a cure and providing hope through innovative research. In 2017 we will be opening four investigator-initiated phase I trials examining cutting-edge treatments for pediatric brain tumors.


  •  Phase I Study of 2-Hydroxyoleic Acid in Pediatric Patients with Malignant Glioma and Other Advanced Solid Tumors

  •  Phase I Trial of the Optune NovoTTF-200A System with and without Concomitant Temozolomide and Bevacizumab in Pediatric Patients with High-grade Glioma

  •  Phase 1 Study of Replication Competent Reovirus (Reolysin®) and GM-CSF in Combination with Standard-of-Care Therapies Pediatric Patients with Brain Tumors

  •  Phase I Study of  Mebendazole for the Treatment of Pediatric Gliomas



Expert Opinions Across Research Institutions and Hospitals


Our program established and leads the New Jersey Pediatric Neuro-oncology Board. The board utilizes a state-of-the-art conferencing system, allowing all participating physicians to be actively involved in the meeting regardless of their location. By partnering with the seven other pediatric cancer centers in the state, our aim is to have every pediatric brain tumor case in New Jersey reviewed by a panel of experts.  The goal of the conference is to improve the quality of care for pediatric brain tumor patients across the state and also help match patients to available clinical trials. 




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